https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26760 Wed 17 Mar 2021 09:57:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26726 Wed 11 Apr 2018 14:21:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13613 Wed 11 Apr 2018 14:02:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20042 Wed 11 Apr 2018 09:27:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47001 Tue 13 Dec 2022 10:59:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5238 Sat 24 Mar 2018 07:44:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49701 Mon 29 May 2023 12:53:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42305 n = 9/group). Statistically different levels of expression were determined (P < 0.05). All nine miRNA mimics significantly affected the proliferation rates of HTR-8/SVneo cells. Five of the miRNA mimics (miR-181a-5p (predicted to target: renin (REN), angiotensin converting enzyme (ACE)), miR-378 (REN, ACE), miR-663 (REN), miR-483-3p (ACE, ACE2, angiotensinogen (AGT), angiotensin II type 1 receptor (AGTR1) and miR-514 (AGT)) were associated with a dose-dependent reduction in cell proliferation. Seven of the mimics significantly decreased expression of at least one of their predicted target RAS mRNAs. Our study shows that miRNAs targeting placental RAS mRNAs play a role in controlling trophoblast proliferation. As placentation is largely a process of proliferation, changes in expression of these miRNAs may be partly responsible for the expression of the placental RAS, proliferation and placentation.]]> Mon 22 Aug 2022 09:00:28 AEST ]]>